I M M U N E T O L E R A N C E I N D U C T I O N S T U D Y

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STUDY OBJECTIVES:

To compare the efficacy, response time, morbidity and economics of a high-dose and a low-dose immune-tolerance protocol.

To identify predictors of successful ITI.

STUDY HYPOTHESES:

High-dose ITI will achieve tolerance more rapidly than low-dose ITI but will have a similar overall success-rate.

Low-dose ITI will be more cost effective than high-dose ITI.

The morbidity associated with the two regimens may be dissimilar.

Lower starting inhibitor titres will be associated with greater success than higher titres.

ITI Study Home Page

	To compare the efficacy, response time, morbidity and economics of a high-dose and a low-dose immune-tolerance protocol.
	To identify predictors of successful ITI.

	High-dose ITI will achieve tolerance more rapidly than low-dose ITI but will have a similar overall success-rate.
	Low-dose ITI will be more cost effective than high-dose ITI.
	The morbidity associated with the two regimens may be dissimilar.
	Lower starting inhibitor titres will be associated with greater success than higher titres.